Cytotoxic constituents from the whole plant of Corydalis pallida

Arch Pharm Res. 2005 Nov;28(11):1224-7. doi: 10.1007/BF02978202.

Abstract

Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 microg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Berberine / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Corydalis / chemistry*
  • Drug Screening Assays, Antitumor
  • Humans
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy

Substances

  • Antineoplastic Agents, Phytogenic
  • Indicators and Reagents
  • Berberine