We report the first case of disseminated fusariosis in an adult patient in Chile, with a hematologic neoplasia and chemotherapy that evolved with febrile prolonged neutropenia, refractory, treated with wide spectrum antibiotics and that developed a systemic infection with sinusal, cutaneous and pulmonary compromise by Fusarium oxysporum. He was refractory to antifungal treatment with amphotericin B deoxycholate and caspofungin that were administered in a sequential schedule. The fatal outcome of this patient was associated to persistent neutropenia and infection caused by a filamentous fungus usually resistant to antifungal therapy.