Abstract
Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-gamma secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-gamma production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Surface / immunology
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Antigens, Surface / metabolism
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Antigens, Surface / physiology*
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CD3 Complex / metabolism
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Cytotoxicity, Immunologic
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Humans
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Interferon-gamma / biosynthesis
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Killer Cells, Natural / immunology
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Lectins, C-Type / immunology
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Lectins, C-Type / metabolism*
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Lectins, C-Type / physiology*
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Ligands
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NK Cell Lectin-Like Receptor Subfamily B
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Protein Binding
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Receptors, Antigen, T-Cell / metabolism
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Receptors, Cell Surface / immunology
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Receptors, Cell Surface / metabolism*
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Signal Transduction
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T-Lymphocytes / metabolism
Substances
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Antigens, Surface
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CD3 Complex
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CLEC2D protein, human
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KLRB1 protein, human
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Lectins, C-Type
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Ligands
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NK Cell Lectin-Like Receptor Subfamily B
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Receptors, Antigen, T-Cell
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Receptors, Cell Surface
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Interferon-gamma