Homologous recombination is promoted by translesion polymerase poleta

Mol Cell. 2005 Dec 9;20(5):658-9. doi: 10.1016/j.molcel.2005.11.018.

Abstract

Two new studies provide in vivo ( [this issue of Molecular Cell]) and in vitro ( [this issue of Molecular Cell]) evidence that poleta functions to extend 3' strands exchanged during homologous recombination and raise the issue of how TLS polymerases are selected onto different substrates.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • DNA / genetics
  • DNA / metabolism*
  • DNA Repair
  • DNA-Directed DNA Polymerase / genetics*
  • DNA-Directed DNA Polymerase / metabolism*
  • Humans
  • Models, Genetic
  • Rad51 Recombinase / metabolism
  • Recombination, Genetic*
  • Sequence Homology, Nucleic Acid

Substances

  • DNA
  • Rad51 Recombinase
  • DNA-Directed DNA Polymerase
  • Rad30 protein