Abstract
The quality control system known as ERAD removes misfolded proteins from the ER to the cytosol for degradation. The AAA ATPase Cdc48p and ubiquitin ligases play crucial roles; their relationship has been unclear, but recent work has shown that the membrane protein Ubx2p links their functions in yeast.
MeSH terms
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Adenosine Triphosphatases
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Cell Cycle Proteins / metabolism*
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Endoplasmic Reticulum / physiology*
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Nuclear Pore Complex Proteins / metabolism
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Nucleocytoplasmic Transport Proteins
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Peptides / metabolism*
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Proteasome Endopeptidase Complex / metabolism
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Protein Folding*
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Saccharomyces cerevisiae Proteins / metabolism
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Ubiquitin-Protein Ligases / metabolism
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Valosin Containing Protein
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Vesicular Transport Proteins
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Yeasts
Substances
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Cell Cycle Proteins
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NPL4 protein, S cerevisiae
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Nuclear Pore Complex Proteins
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Nucleocytoplasmic Transport Proteins
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Peptides
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Saccharomyces cerevisiae Proteins
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UFD1 protein, S cerevisiae
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Vesicular Transport Proteins
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Ubiquitin-Protein Ligases
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Proteasome Endopeptidase Complex
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Adenosine Triphosphatases
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CDC48 protein, S cerevisiae
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Valosin Containing Protein