Quality control: another player joins the ERAD cast

Curr Biol. 2005 Dec 6;15(23):R963-4. doi: 10.1016/j.cub.2005.11.013.

Abstract

The quality control system known as ERAD removes misfolded proteins from the ER to the cytosol for degradation. The AAA ATPase Cdc48p and ubiquitin ligases play crucial roles; their relationship has been unclear, but recent work has shown that the membrane protein Ubx2p links their functions in yeast.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases
  • Cell Cycle Proteins / metabolism*
  • Endoplasmic Reticulum / physiology*
  • Nuclear Pore Complex Proteins / metabolism
  • Nucleocytoplasmic Transport Proteins
  • Peptides / metabolism*
  • Proteasome Endopeptidase Complex / metabolism
  • Protein Folding*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Ubiquitin-Protein Ligases / metabolism
  • Valosin Containing Protein
  • Vesicular Transport Proteins
  • Yeasts

Substances

  • Cell Cycle Proteins
  • NPL4 protein, S cerevisiae
  • Nuclear Pore Complex Proteins
  • Nucleocytoplasmic Transport Proteins
  • Peptides
  • Saccharomyces cerevisiae Proteins
  • UFD1 protein, S cerevisiae
  • Vesicular Transport Proteins
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex
  • Adenosine Triphosphatases
  • CDC48 protein, S cerevisiae
  • Valosin Containing Protein