Antiarrhythmic activity of 4,6-di(het)aryl-5-nitro-3,4-dihydropyrimidin-(1H)-2-ones and its effects on arterial pressure in rats

Arkadiy O Bryzgalov; Margarita P Dolgikh; Irina V Sorokina; Tatiana G Tolstikova; Valentina F Sedova; Oleg P Shkurko

doi:10.1016/j.bmcl.2005.11.043

Antiarrhythmic activity of 4,6-di(het)aryl-5-nitro-3,4-dihydropyrimidin-(1H)-2-ones and its effects on arterial pressure in rats

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1418-20. doi: 10.1016/j.bmcl.2005.11.043.

Authors

Arkadiy O Bryzgalov¹, Margarita P Dolgikh, Irina V Sorokina, Tatiana G Tolstikova, Valentina F Sedova, Oleg P Shkurko

Affiliation

¹ N.N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation. arkadiy@nioch.nsc.ru

PMID: 16321526
DOI: 10.1016/j.bmcl.2005.11.043

Abstract

The antiarrhythmic activity of 4,6-di(het)aryl-5-nitro-3,4-dihydropyrimidin-(1H)-2-ones toward two types of experimental rat arrhythmia has been studied. With CaCl(2) induced arrhythmia model, several agents have demonstrated high antiarrhythmic activity and the lack of influence on arterial pressure of rats.

MeSH terms

Animals
Anti-Arrhythmia Agents / chemistry*
Anti-Arrhythmia Agents / pharmacology*
Blood Pressure / drug effects*
Male
Molecular Structure
Pyrimidines / chemistry*
Pyrimidines / pharmacology*
Rats
Structure-Activity Relationship

Substances

Anti-Arrhythmia Agents
Pyrimidines
pyrimidine