Five labdane diterpenoids from the seeds of Aframomum zambesiacum

Phytochemistry. 2006 Mar;67(5):433-8. doi: 10.1016/j.phytochem.2005.10.015.

Abstract

Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC(50) value of 4.97 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology
  • Diterpenes / chemistry*
  • Diterpenes / classification
  • Diterpenes / therapeutic use
  • Parasitic Sensitivity Tests
  • Plasmodium falciparum / drug effects
  • Seeds / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Zingiberaceae / chemistry*

Substances

  • Antimalarials
  • Diterpenes
  • labdane