Abstract
Eight new meroditerpenoid-related metabolites, including one naphthoquinone derivative, chabrolonaphthoquinone B (1), four tetraprenyltoluquinone-related compounds, chabrolobenzoquinones E-H (2-5), and three tetraprenyltoluquinol-related metabolites, chabrolohydroxybenzoquinones E-G (6-8), were isolated from the organic extract of a Taiwanese soft coral Nephthea chabrolii. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of the related metabolites. Cytotoxic activity of metabolites 1-3 and 5-8 against a limited panel of cancer cell lines is also described.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anthozoa / chemistry*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology
-
Benzoquinones / chemistry
-
Benzoquinones / isolation & purification
-
Benzoquinones / pharmacology
-
Diterpenes / chemistry
-
Diterpenes / isolation & purification*
-
Diterpenes / pharmacology
-
Drug Screening Assays, Antitumor
-
Humans
-
Inhibitory Concentration 50
-
Molecular Structure
-
Naphthoquinones / chemistry
-
Naphthoquinones / isolation & purification*
-
Naphthoquinones / pharmacology
-
Taiwan
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Benzoquinones
-
Diterpenes
-
Naphthoquinones
-
chabrolonaphthoquinone B