Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways

Antimicrob Agents Chemother. 2005 Dec;49(12):5146-8. doi: 10.1128/AAC.49.12.5146-5148.2005.

Abstract

Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 microg/ml. This phenomenon was markedly attenuated in a deltamkc1/deltamkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Calcineurin / metabolism*
  • Calcineurin Inhibitors
  • Candida albicans / drug effects*
  • Candida albicans / physiology
  • Caspofungin
  • Cell Wall / drug effects*
  • Cell Wall / physiology
  • Drug Resistance, Microbial / physiology*
  • Echinocandins
  • Gene Expression Regulation, Fungal / physiology
  • Lipopeptides
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / pharmacology*

Substances

  • Antifungal Agents
  • Calcineurin Inhibitors
  • Echinocandins
  • Lipopeptides
  • Peptides, Cyclic
  • Calcineurin
  • Caspofungin