This was a multi-site, 231-subject double-masked, bilateral crossover study to evaluate subjective comfort and satisfaction, corneal staining and lens deposits with two 'no rub' multi-purpose solutions (MPS) used with FDA Group II (alphafilcon A, SofLens 66, Bausch & Lomb) and Group IV (etafilcon A, SUREVUE, Johnson & Johnson Vision Care) soft contact lenses. Subjects used each of the two MPS, Regimen 1 (OPTI-FREE EXPRESS Multi-Purpose Disinfecting Solution No Rub Lasting Comfort Formula, Alcon Laboratories) and Regimen 2 (ReNu MultiPlus Multi-Purpose Solution, Bausch & Lomb), for 28 days. They wore the same lens type for the duration of the study and were evaluated on days 0, 14 and 28 of each treatment period. Subjective ratings of comfort and satisfaction were significantly different between regimens, with the majority of variables in favour of Regimen 1 (P < 0.05). Corneal staining was significantly greater with the Group II, Regimen 2 combination (P < 0.0001). Group IV lenses cared for with Regimen 1 had significantly less residual lysozyme on Day 28 (562 microg) than lenses cared for with Regimen 2 (1145 microg; P < 0.0001). While both products offer the convenience of a 'no rub' regimen, differences in performance should be considered when recommending these solutions to patients.