Transposition is described as an interchange in the position of two teeth within the same quadrant of the dental arch. Canine transposition is reportedly the most common transposition in human dentition. The incidence of maxillary canine-premolar transposition is reported to be 0.135-0.510%. Although the exact mechanism of canine transposition is unclear, it seems to be closely related to genetically influenced, retained deciduous canine, and a history of trauma. In this article, we focus on the classification, incidence, etiology, and treatment modalities of tooth transposition. We hope this information will help clinicians treating patients with this kind of dental anomaly.