Ruthenium-catalyzed cycloaddition of alkynes and organic azides

J Am Chem Soc. 2005 Nov 23;127(46):15998-9. doi: 10.1021/ja054114s.

Abstract

Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective "fusion" of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylene / analogs & derivatives
  • Acetylene / chemistry
  • Alkynes / chemistry*
  • Azides / chemistry*
  • Catalysis
  • Molecular Structure
  • Ruthenium / chemistry*

Substances

  • Alkynes
  • Azides
  • phenylacetylene
  • Ruthenium
  • Acetylene