An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor

Charles A Dinarello

doi:10.1016/j.immuni.2005.10.004

An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor

Immunity. 2005 Nov;23(5):461-2. doi: 10.1016/j.immuni.2005.10.004.

Author

Charles A Dinarello¹

Affiliation

¹ University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

PMID: 16286013
DOI: 10.1016/j.immuni.2005.10.004

Abstract

Activation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper type 2 (T(H)2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates much of the existing data that ST2 promotes T(H)2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases.

MeSH terms

Animals
Caspase 1 / metabolism*
Humans
Interleukin-1 / classification*
Interleukin-1 / immunology
Interleukin-1 / metabolism*
Receptors, Cell Surface / immunology
Receptors, Cell Surface / metabolism*
Signal Transduction*

Substances

Interleukin-1
Receptors, Cell Surface
Caspase 1