The enigmatic role of Sir2 in aging

Cell. 2005 Nov 18;123(4):548-50. doi: 10.1016/j.cell.2005.11.002.

Abstract

In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.

Publication types

  • Comment

MeSH terms

  • Alcohol Dehydrogenase / metabolism
  • Cyclic AMP-Dependent Protein Kinases / genetics
  • Cyclic AMP-Dependent Protein Kinases / physiology
  • Ethanol / metabolism
  • Histone Deacetylases / genetics
  • Histone Deacetylases / physiology*
  • Hot Temperature
  • Models, Biological
  • Mutation / genetics
  • Oxidative Stress
  • Protein Kinases / genetics
  • Protein Kinases / physiology
  • Protein Serine-Threonine Kinases
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / physiology
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae / physiology*
  • Sirtuin 1
  • Sirtuin 2
  • Sirtuins / genetics
  • Sirtuins / physiology*
  • Time Factors

Substances

  • Saccharomyces cerevisiae Proteins
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • Ethanol
  • Alcohol Dehydrogenase
  • Protein Kinases
  • SCH9 protein kinase
  • Protein Serine-Threonine Kinases
  • target of rapamycin protein, S cerevisiae
  • Cyclic AMP-Dependent Protein Kinases
  • SIR2 protein, S cerevisiae
  • Sirt1 protein, mouse
  • Sirtuin 1
  • Sirtuin 2
  • Sirtuins
  • Histone Deacetylases