Evidence is increasing that proto-oncogenes and cancer suppressor genes are involved in the development and/or progression of gynecological malignancies. While histopathologic examination remains an indispensable tool of the surgical pathologist in the diagnosis and evaluation of patients with gynecological malignancies, the advancement to technology and the development of new knowledge regarding neoplastic transformation are providing a basis for new opportunities to improve patients care. These new opportunities will depend on the use of the skills and reagents developed in the basic medical science laboratories. Thus, it is important for those in the field of diagnostic pathology to begin to acquire a knowledge of proto-oncogenes and cancer suppressor genes as well as a basic understanding of the techniques used to detect and evaluate them.