CSF amyloid beta42 and tau levels correlate with AIDS dementia complex

Neurology. 2005 Nov 8;65(9):1490-2. doi: 10.1212/01.wnl.0000183293.95787.b7.

Abstract

There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF beta-amyloid(1-42) (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF Abeta42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Dementia Complex / cerebrospinal fluid*
  • AIDS Dementia Complex / diagnosis
  • AIDS Dementia Complex / virology
  • Adult
  • Alzheimer Disease / cerebrospinal fluid*
  • Alzheimer Disease / diagnosis
  • Amyloid beta-Peptides / cerebrospinal fluid*
  • Biomarkers / cerebrospinal fluid
  • Brain / metabolism
  • Brain / physiopathology
  • Brain / virology
  • Female
  • HIV-1 / isolation & purification
  • Humans
  • Male
  • Middle Aged
  • Neopterin / cerebrospinal fluid
  • Peptide Fragments / cerebrospinal fluid*
  • Phosphorylation
  • Predictive Value of Tests
  • RNA, Viral / cerebrospinal fluid
  • Reference Values
  • Viral Load
  • tau Proteins / cerebrospinal fluid*

Substances

  • Amyloid beta-Peptides
  • Biomarkers
  • Peptide Fragments
  • RNA, Viral
  • amyloid beta-protein (1-42)
  • tau Proteins
  • Neopterin