Abstract
There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF beta-amyloid(1-42) (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF Abeta42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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AIDS Dementia Complex / cerebrospinal fluid*
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AIDS Dementia Complex / diagnosis
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AIDS Dementia Complex / virology
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Adult
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Alzheimer Disease / cerebrospinal fluid*
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Alzheimer Disease / diagnosis
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Amyloid beta-Peptides / cerebrospinal fluid*
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Biomarkers / cerebrospinal fluid
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Brain / metabolism
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Brain / physiopathology
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Brain / virology
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Female
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HIV-1 / isolation & purification
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Humans
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Male
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Middle Aged
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Neopterin / cerebrospinal fluid
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Peptide Fragments / cerebrospinal fluid*
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Phosphorylation
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Predictive Value of Tests
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RNA, Viral / cerebrospinal fluid
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Reference Values
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Viral Load
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tau Proteins / cerebrospinal fluid*
Substances
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Amyloid beta-Peptides
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Biomarkers
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Peptide Fragments
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RNA, Viral
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amyloid beta-protein (1-42)
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tau Proteins
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Neopterin