Aminoarenethiolate-copper(I)-catalyzed amination of aryl bromides

Thomas Jerphagnon; Gerard P M van Klink; Johannes G de Vries; Gerard van Koten

doi:10.1021/ol052113z

Aminoarenethiolate-copper(I)-catalyzed amination of aryl bromides

Org Lett. 2005 Nov 10;7(23):5241-4. doi: 10.1021/ol052113z.

Authors

Thomas Jerphagnon¹, Gerard P M van Klink, Johannes G de Vries, Gerard van Koten

Affiliation

¹ Debye Institute, Organic Chemistry and Catalysis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

PMID: 16268548
DOI: 10.1021/ol052113z

Abstract

[reaction, structure: see text] Aminoarenethiolate-copper(I) complexes are known to be efficient catalysts for carbon-carbon bond formation. Here, we show the first examples that these thiolate-copper(I) complexes are efficient for carbon-nitrogen bond formation reactions as well. N-Arylation of benzylamine and imidazole with bromobenzene was achieved either in NMP as solvent or under solvent-free conditions in the presence of 2.5 mol % of aminoarenethiolate-copper(I) complex only.