Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: preliminary report of two cases

S Suzuki; O Ito; T Sayama; S Yamaguchi; K Goto; T Sasaki

doi:10.1007/s00234-005-0014-7

Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: preliminary report of two cases

Neuroradiology. 2006 Jan;48(1):50-3. doi: 10.1007/s00234-005-0014-7. Epub 2005 Oct 28.

Authors

S Suzuki¹, O Ito, T Sayama, S Yamaguchi, K Goto, T Sasaki

Affiliation

¹ Department of Neurological Surgery, Shin-Koga Hospital, Kurume, 830-8577, Japan. suzuki.s@ns.yawata-mhp.or.jp

PMID: 16261335
DOI: 10.1007/s00234-005-0014-7

Abstract

We describe two patients with symptomatic vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin daropate hydrochloride (HCl). Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated intracellular concentrations of cyclic adenosine monophosphate. We suggest that colforsin daropate HCl might be a useful therapeutic tool in treating cerebral vasospasm.

Publication types

Case Reports

MeSH terms

Cerebral Angiography
Colforsin / administration & dosage
Colforsin / analogs & derivatives*
Colforsin / therapeutic use
Female
Humans
Injections, Intra-Arterial
Middle Aged
Subarachnoid Hemorrhage / complications
Subarachnoid Hemorrhage / diagnosis
Subarachnoid Hemorrhage / drug therapy*
Tomography, Emission-Computed, Single-Photon
Vasospasm, Intracranial / diagnosis
Vasospasm, Intracranial / drug therapy*
Vasospasm, Intracranial / etiology

Substances

colforsin daropate
Colforsin