The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids

Chem Commun (Camb). 2005 Nov 21:(43):5438-40. doi: 10.1039/b510707e. Epub 2005 Oct 4.

Abstract

Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids / chemistry*
  • Carboxylic Acids / pharmacology*
  • Models, Molecular
  • Oxygenases / metabolism
  • Protein Biosynthesis
  • Protein Structure, Tertiary
  • Repressor Proteins / antagonists & inhibitors*
  • Repressor Proteins / chemistry
  • Repressor Proteins / metabolism
  • Transcription Factors / antagonists & inhibitors*
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism

Substances

  • Carboxylic Acids
  • Repressor Proteins
  • Transcription Factors
  • Oxygenases