Two new antioxidant stilbene dimers, parthenostilbenins A and B from Parthenocissus tricuspidata

Planta Med. 2005 Oct;71(10):973-6. doi: 10.1055/s-2005-871229.

Abstract

The ethyl acetate fraction of an aqueous alcoholic extract from the stem of Parthenocissus tricuspidata yielded 11 known compounds (1-11) and two new stilbene dimers parthenostilbenins A (12) and B (13) upon purification either by preparative TLC or reversed phase HPLC. The structures of the new isolates were identified using a combination of FAB-MS and NMR. These compounds were assessed for antioxidant activities in three different bioassay systems. Among them, piceatannol showed the strongest inhibitory activity in these assay systems. Two new compounds, parthenostilbenins A (12) and B (13) inhibited lipid peroxidation (IC (50) = 20.35 +/- 1.22 and 18.68 +/- 0.51 microg/mL, respectively) in a rat liver homogenate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Biphenyl Compounds
  • Inhibitory Concentration 50
  • Lipid Peroxidation / drug effects*
  • Phytotherapy*
  • Picrates / chemistry
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Stilbenes / administration & dosage
  • Stilbenes / chemistry
  • Stilbenes / pharmacology
  • Stilbenes / therapeutic use
  • Vitaceae*

Substances

  • Antioxidants
  • Biphenyl Compounds
  • Picrates
  • Plant Extracts
  • Stilbenes
  • 1,1-diphenyl-2-picrylhydrazyl