Mechanism underlying the effect of myelopeptides on lymphocyte proliferation in vitro

T V Gavrilova; S V Gein; T A Pogudina; V A Chereshnev

doi:10.1007/s10517-005-0415-y

Mechanism underlying the effect of myelopeptides on lymphocyte proliferation in vitro

Bull Exp Biol Med. 2005 Jul;140(1):74-6. doi: 10.1007/s10517-005-0415-y.

Authors

T V Gavrilova¹, S V Gein, T A Pogudina, V A Chereshnev

Affiliation

¹ Analytical Laboratory, Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm.

PMID: 16254625
DOI: 10.1007/s10517-005-0415-y

Abstract

We studied the role of monocytes in the effect of myelopid and myelopeptides MP-1, MP-3, MP-5, and MP-6 on functional activity of peripheral blood lymphocytes in the reaction of blast transformation. Myelopeptides MP-1, MP-3, and MP-6 suppressed blast transformation of lymphocytes. The effect depended on the presence of monocytes in a cell culture.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Analysis of Variance
Dose-Response Relationship, Drug
Humans
Immunologic Factors / immunology*
Immunologic Factors / pharmacology
Leukocytes, Mononuclear / cytology*
Leukocytes, Mononuclear / drug effects*
Lymphocyte Activation / drug effects*
Male
Oligopeptides / immunology*
Oligopeptides / pharmacology
Scintillation Counting

Substances

Immunologic Factors
Oligopeptides
myelopeptides