Quassinoids from the leaves of the Madagascan Simaroubaceae Samadera madagascariensis

Philip H Coombes; Dashnie Naidoo; Dulcie A Mulholland; Milijaona Randrianarivelojosia

doi:10.1016/j.phytochem.2005.09.005

Quassinoids from the leaves of the Madagascan Simaroubaceae Samadera madagascariensis

Phytochemistry. 2005 Dec;66(23):2734-9. doi: 10.1016/j.phytochem.2005.09.005. Epub 2005 Oct 25.

Authors

Philip H Coombes¹, Dashnie Naidoo, Dulcie A Mulholland, Milijaona Randrianarivelojosia

Affiliation

¹ School of Chemistry, University of KwaZulu-Natal, Howard College Campus, Durban 4041, South Africa.

PMID: 16253298
DOI: 10.1016/j.phytochem.2005.09.005

Abstract

An investigation of the leaves of the Madagascan Simaroubaceae Samadera madagascariensis has yielded three C18 quassinoids, 5beta,6-dihydrosamaderine A, 2-chlorosamaderine A, and samaderolactone A, and a C19 quassinoid, 3,4beta-dihydrosamaderine C, together with the known quassinoids samaderine A, samaderine B, and cedronin. The compounds isolated displayed little or no anti-tumour activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Humans
Madagascar
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Leaves / chemistry*
Quassins / chemistry*
Quassins / isolation & purification
Quassins / pharmacology
Simaroubaceae / chemistry*
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Quassins
cedronin
samaderin A
samaderin B

Grants and funding

Wellcome Trust/United Kingdom