Abstract
The effects of a selective serotonin reuptake inhibitor, citalopram, and a tricyclic antidepressant drug, imipramine, administered repetitively for 14 days, were investigated ex vivo in rat hippocampal slices. Spontaneous epileptiform bursts were recorded from the CA3 area in nominally Mg(2+)-free incubation conditions. 5-carboxamidotryptamine (5-CT) dose-dependently increased bursting frequency in the presence of N-[2-[4-(2-methoxyphenyl)-1 piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide (WAY 100635). This effect could be dose-dependently blocked by (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride (SB 269970), thus implicating the involvement of 5-HT(7) receptors. Repeated treatment with citalopram or imipramine resulted in an attenuation of the excitatory effects of the activation of hippocampal 5-HT(7) receptor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Antidepressive Agents / pharmacology
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Citalopram / administration & dosage
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Citalopram / pharmacology*
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Dose-Response Relationship, Drug
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Hippocampus / drug effects*
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Hippocampus / physiopathology
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Imipramine / administration & dosage
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Imipramine / pharmacology*
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In Vitro Techniques
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Male
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Phenols / pharmacology
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Piperazines / pharmacology
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Pyridines / pharmacology
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Rats
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Rats, Wistar
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Receptors, Serotonin / physiology*
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Serotonin / analogs & derivatives
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Serotonin / pharmacology
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Serotonin Antagonists / pharmacology
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Serotonin Receptor Agonists / pharmacology
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Sulfonamides / pharmacology
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Time Factors
Substances
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Antidepressive Agents
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Phenols
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Piperazines
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Pyridines
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Receptors, Serotonin
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SB 269970
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Serotonin Antagonists
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Serotonin Receptor Agonists
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Sulfonamides
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serotonin 7 receptor
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Citalopram
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Serotonin
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N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
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5-carboxamidotryptamine
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Imipramine