Abstract
Three new steroidal saponins (1-3) were isolated from the roots of Smilax medica, together with the known disporoside A (4). The structures of the new compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS, and HRESIMS). Compounds 1, 2, and 4 demonstrated weak antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata, and C.tropicalis, with MIC values between 12.5 and 50 microg/mL.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Candida / drug effects*
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Humans
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Mexico
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Smilax / chemistry*
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Steroids / chemistry
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Steroids / isolation & purification*
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Steroids / pharmacology
Substances
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Antifungal Agents
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Saponins
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Steroids
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disporoside A