Abstract
Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Antioxidants / chemical synthesis*
-
Antioxidants / chemistry
-
Humans
-
Lipid Peroxidation*
-
Lipoproteins, LDL / blood
-
Lipoproteins, LDL / chemistry*
-
Pyridines / chemical synthesis*
-
Pyridines / chemistry
-
Structure-Activity Relationship
-
Tryptophan / chemistry
-
alpha-Tocopherol / blood
-
alpha-Tocopherol / chemistry*
Substances
-
Antioxidants
-
Lipoproteins, LDL
-
Pyridines
-
3-hydroxypyridine
-
Tryptophan
-
alpha-Tocopherol