The stereochemistry of ketoreduction

Chem Biol. 2005 Oct;12(10):1060-2. doi: 10.1016/j.chembiol.2005.10.002.

Abstract

In this issue of Chemistry & Biology, Leadlay and coworkers report overproduction of a number of ketoreductase domains from modular polyketide synthases. These discrete enzymes allow the stereochemistry of polyketide ketoreduction to be studied in isolation.

Publication types

  • Comment
  • Review

MeSH terms

  • Alcohol Oxidoreductases / chemistry*
  • Binding Sites
  • Ketones / chemistry
  • Oxidation-Reduction*
  • Protein Structure, Tertiary
  • Stereoisomerism

Substances

  • Ketones
  • Alcohol Oxidoreductases