Bio-guided isolation of the cytotoxic corytenchine and isocoreximine from roots of Annona cherimolia

Mariano Martínez-Vázquez; Diana G De la Cueva Lozano; Rosa Estrada-Reyes; Nadia Margarita González-Lugo; Teresa Ramírez Apan; Gerardo Heinze

doi:10.1016/j.fitote.2005.08.004

Bio-guided isolation of the cytotoxic corytenchine and isocoreximine from roots of Annona cherimolia

Fitoterapia. 2005 Dec;76(7-8):733-6. doi: 10.1016/j.fitote.2005.08.004. Epub 2005 Oct 19.

Authors

Mariano Martínez-Vázquez¹, Diana G De la Cueva Lozano, Rosa Estrada-Reyes, Nadia Margarita González-Lugo, Teresa Ramírez Apan, Gerardo Heinze

Affiliation

¹ Instituto de Química, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F. México.

PMID: 16242261
DOI: 10.1016/j.fitote.2005.08.004

Abstract

The roots of Annona cherimolia have been shown to contain the known tetrahydroprotoberberine alkaloids corytenchine (1) and isocoreximine (2), investigated for their cytotoxic properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / isolation & purification*
Alkaloids / pharmacology*
Annona / chemistry*
Antineoplastic Agents, Phytogenic / analysis
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Berberine Alkaloids / chemistry
Berberine Alkaloids / isolation & purification*
Berberine Alkaloids / pharmacology*
Cell Line, Tumor / drug effects
Humans
Plant Roots / chemistry

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Berberine Alkaloids
corytenchine
isocoreximine