Abstract
We report a 50-year-old patient with idiopathic hypereosinophilic syndrome with trisomy 8 who experienced a complete and durable hematological and cytogenetic remission with low-dose imatinib therapy. He also had a significant reversal of cardiac dysfunction with a reduction in cardiac hypertrophy, resolution of pericardial effusion and mitral and tricuspid regurgitation. He remained in remission 3 years after therapy.
MeSH terms
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Aortic Valve Insufficiency
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Benzamides
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Cardiomegaly
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Chromosomes, Human, Pair 8*
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Cytogenetic Analysis
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Heart Diseases*
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Humans
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Hypereosinophilic Syndrome / complications*
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Hypereosinophilic Syndrome / drug therapy*
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Hypereosinophilic Syndrome / genetics
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Imatinib Mesylate
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Middle Aged
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Mitral Valve Insufficiency
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Piperazines / therapeutic use*
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Pyrimidines / therapeutic use*
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Remission Induction / methods
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Trisomy*
Substances
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Benzamides
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Piperazines
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Pyrimidines
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Imatinib Mesylate