Highly stereoselective reductions of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters catalyzed by isolated NADPH-dependent ketoreductases

Dimitris Kalaitzakis; J David Rozzell; Spiros Kambourakis; Ioulia Smonou

doi:10.1021/ol051166d

Highly stereoselective reductions of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters catalyzed by isolated NADPH-dependent ketoreductases

Org Lett. 2005 Oct 27;7(22):4799-801. doi: 10.1021/ol051166d.

Authors

Dimitris Kalaitzakis¹, J David Rozzell, Spiros Kambourakis, Ioulia Smonou

Affiliation

¹ Department of Chemistry, University of Crete, Greece.

PMID: 16235892
DOI: 10.1021/ol051166d

Abstract

[reaction: see text] The biocatalytic reduction of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Esters / chemistry*
Esters / metabolism
Ketones / chemistry*
Ketones / metabolism
Molecular Structure
NADP / chemistry*
Oxidation-Reduction
Oxidoreductases / chemistry*
Stereoisomerism

Substances

Esters
Ketones
NADP
Oxidoreductases