Cytotoxic activities of ethyl acetate extract and a metabolite from a Monocillium species

Phytother Res. 2005 Sep;19(9):816-7. doi: 10.1002/ptr.1730.

Abstract

The ethyl acetate soluble fraction of a cultural broth of a Monocillium species afforded the isolation of 5-hydroxymethylfurfural. Both the extract and 5-hydroxymethylfurfural showed significant cytotoxic activities in a brine shrimp bioassay and the LC(50) values were found to be 14.96 microg/mL and 23.71 microg/mL, respectively.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / toxicity*
  • Artemia / drug effects
  • Furaldehyde / analogs & derivatives
  • Furaldehyde / toxicity
  • Lethal Dose 50
  • Mitosporic Fungi / metabolism*
  • Phytotherapy*
  • Plant Extracts / toxicity*
  • Plants, Medicinal*

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • 5-hydroxymethylfurfural
  • Furaldehyde