Iterative, orthogonal strategy for oligosaccharide synthesis based on the regioselective glycosylation of polyol acceptors with partially unprotected n-pentenyl-orthoesters: further evidence for reciprocal donor acceptor selectivity (RDAS)

J Cristóbal López; Attila Agocs; Clara Uriel; Ana M Gómez; Bert Fraser-Reid

doi:10.1039/b507468a

Iterative, orthogonal strategy for oligosaccharide synthesis based on the regioselective glycosylation of polyol acceptors with partially unprotected n-pentenyl-orthoesters: further evidence for reciprocal donor acceptor selectivity (RDAS)

Chem Commun (Camb). 2005 Oct 28:(40):5088-90. doi: 10.1039/b507468a. Epub 2005 Sep 14.

Authors

J Cristóbal López¹, Attila Agocs, Clara Uriel, Ana M Gómez, Bert Fraser-Reid

Affiliation

¹ Instituto de Química Orgánica General, CSIC, Juan de la Cierva 3, 28006, Madrid, Spain. clopez@iqog.csic.es

PMID: 16220180
DOI: 10.1039/b507468a

Abstract

An efficient iterative, orthogonal protocol based on the regioselective glycosyl coupling of D-mannose polyols with, partially unprotected, n-pentenyl orthoester donors permits the synthesis of linear and branched oligosaccharides with minimal protecting group tampering.