Abstract
Biological rhythms with periods of less than a day are physiologically important but poorly understood. In this issue of Cell, Norman, Maricq, and colleagues (Norman et al., 2005) show that VAV-1, a guanine nucleotide exchange factor for Rho-family GTPases, is necessary for three rhythmic behaviors in the nematode Caenorhabditis elegans: feeding, defecation, and ovulation.
MeSH terms
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Animals
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Biological Clocks / physiology*
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Caenorhabditis elegans Proteins / metabolism
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Calcium Signaling / physiology
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Defecation / physiology
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Feeding Behavior / physiology
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GTP Phosphohydrolases / metabolism
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Humans
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Ovulation / physiology
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Periodicity*
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Proto-Oncogene Proteins c-vav / genetics
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Proto-Oncogene Proteins c-vav / metabolism*
Substances
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Caenorhabditis elegans Proteins
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Proto-Oncogene Proteins c-vav
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Vav1 protein, mouse
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GTP Phosphohydrolases