VAV's got rhythm

Cell. 2005 Oct 7;123(1):5-7. doi: 10.1016/j.cell.2005.09.018.

Abstract

Biological rhythms with periods of less than a day are physiologically important but poorly understood. In this issue of Cell, Norman, Maricq, and colleagues (Norman et al., 2005) show that VAV-1, a guanine nucleotide exchange factor for Rho-family GTPases, is necessary for three rhythmic behaviors in the nematode Caenorhabditis elegans: feeding, defecation, and ovulation.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Caenorhabditis elegans Proteins / metabolism
  • Calcium Signaling / physiology
  • Defecation / physiology
  • Feeding Behavior / physiology
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Ovulation / physiology
  • Periodicity*
  • Proto-Oncogene Proteins c-vav / genetics
  • Proto-Oncogene Proteins c-vav / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • Proto-Oncogene Proteins c-vav
  • Vav1 protein, mouse
  • GTP Phosphohydrolases