Alternative splicing--when two's a crowd

Cell. 2005 Oct 7;123(1):1-3. doi: 10.1016/j.cell.2005.09.010.

Abstract

Various mechanisms have been proposed to explain mutually exclusive splicing of pairs of exons. A paper in this issue of Cell (Graveley, 2005) provides a fascinating insight into the perplexing question of how only one exon at a time is chosen from an array of 48 exons in the Drosophila Dscam gene.

Publication types

  • Review
  • Comment

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Cell Adhesion Molecules
  • Drosophila Proteins / biosynthesis
  • Drosophila Proteins / genetics*
  • Drosophila melanogaster / genetics*
  • Exons / genetics*
  • Gene Expression Regulation / genetics*
  • Humans
  • RNA Splice Sites / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Spliceosomes / genetics

Substances

  • Cell Adhesion Molecules
  • Drosophila Proteins
  • Dscam1 protein, Drosophila
  • RNA Splice Sites
  • RNA, Messenger