Abstract
From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, beta-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, beta-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 microg/ml and showed antiplasmodial activity with an IC50 value of 7.2 microg/ml. Compounds 2 and 3 were inactive in both assays.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / isolation & purification
-
Anti-Bacterial Agents / pharmacology*
-
Antimalarials / chemistry*
-
Antimalarials / isolation & purification
-
Antimalarials / pharmacology*
-
Drug Evaluation, Preclinical
-
Fatty Acids, Unsaturated / chemistry*
-
Fatty Acids, Unsaturated / isolation & purification
-
Fatty Acids, Unsaturated / pharmacology*
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Mycobacterium tuberculosis / drug effects
-
Parasitic Sensitivity Tests
-
Plasmodium falciparum / drug effects
-
Santalaceae / chemistry*
-
Santalaceae / classification
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Antimalarials
-
Fatty Acids, Unsaturated
-
scleropyric acid