Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum

Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1327-9. doi: 10.1248/cpb.53.1327.

Abstract

From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, beta-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, beta-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 microg/ml and showed antiplasmodial activity with an IC50 value of 7.2 microg/ml. Compounds 2 and 3 were inactive in both assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Antimalarials / chemistry*
  • Antimalarials / isolation & purification
  • Antimalarials / pharmacology*
  • Drug Evaluation, Preclinical
  • Fatty Acids, Unsaturated / chemistry*
  • Fatty Acids, Unsaturated / isolation & purification
  • Fatty Acids, Unsaturated / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Parasitic Sensitivity Tests
  • Plasmodium falciparum / drug effects
  • Santalaceae / chemistry*
  • Santalaceae / classification
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Antimalarials
  • Fatty Acids, Unsaturated
  • scleropyric acid