Cystoid oedema of macula is the most frequent problem following non-complicated cataract surgery, which leads to weakening of visual acutity. We have studied the treatment outcomes of the topical therapy with corticosteroids and nonsteroid antirheumatics during prospective randomized study in comparison with orally applied acethazolamide. However, 8 weeks later in treatment was observed a positive effect in both groups, on the eyes of patients, treated with acetazolamide, resorption of the oedema was faster, more intensive and ultimate visual acutity was statistically significantly better. Results demonstrated a benefit of combined therapy with antiinflamative drugs and orally prescribed acetazolamide in pseudophakic macular oedema.