Tendinopathy is a common and substantial source of morbidity worldwide. Various anatomical and functional predispositions combine with abrupt changes in mechanical loading to cause characteristic histological maladaptations in tendons. The nature and latency of cellular changes in tendinopathy makes many common treatments less-than-optimal options. This Perspective presents the EdUReP model for nonsurgical management of tendinopathy, a model that considers sources of pathology at the cellular, anatomical, and functional levels. The EdUReP model addresses possible sources of symptoms at the levels of pathology, impairment, functional limitation, and disability through Educational interventions, periods of tendon Unloading and controlled Reloading, and implementation of Prevention strategies. The EdUReP model is an evidence-based treatment construct that aims to reduce functional limitation and disability through amelioration of tissue pathology.