Thrombospondin modulates basic fibroblast growth factor activities on endothelial cells

EXS. 1992:61:210-3. doi: 10.1007/978-3-0348-7001-6_32.

Abstract

We previously reported that thrombospondin (TSP) induces endothelial cell (EC) adhesion, spreading and motility, suggesting that it can play a role in angiogenesis. We then studied whether TSP might modulate EC response to known angiogenic stimuli in vitro. Here we describe that TSP inhibits EC chemotactic response to basic fibroblast growth factor (bFGF). Furthermore, TSP and its 140 kD fragment reduce EC proliferative response to serum and bFGF. These data support the indicated role of TSP and its 140 kD fragment in angiogenesis and in related pathologies including tumor malignancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta
  • Blood Platelets / physiology
  • Cattle
  • Cell Division / drug effects
  • Cell Movement / drug effects
  • Cells, Cultured
  • Chemotaxis / drug effects
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiology*
  • Fibroblast Growth Factor 2 / pharmacology*
  • Humans
  • Platelet Membrane Glycoproteins / isolation & purification
  • Platelet Membrane Glycoproteins / physiology*
  • Recombinant Proteins / pharmacology
  • Thrombospondins

Substances

  • Platelet Membrane Glycoproteins
  • Recombinant Proteins
  • Thrombospondins
  • Fibroblast Growth Factor 2