Atrovirisidone B, a new prenylated depsidone with cytotoxic property from the roots of Garcinia atroviridis

Z Naturforsch C J Biosci. 2005 Jul-Aug;60(7-8):523-6. doi: 10.1515/znc-2005-7-802.

Abstract

A new prenylated depsidone, atrovirisidone B (2), together with naringenin (3) and 3,8"-binaringenin (4) were isolated from the roots of Garcinia atroviridis. Their structures were determined on the basis of spectral data interpretation. Compound 2 showed cytotoxic activity against human breast (MCF-7), human prostate (DU-145) and human lung (H-460) cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms
  • Cell Line, Tumor
  • Cell Survival / drug effects*
  • Female
  • Garcinia / chemistry*
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / toxicity
  • Male
  • Models, Molecular
  • Plant Roots / chemistry*
  • Prostatic Neoplasms

Substances

  • Lactones
  • atrovirisidone