Circular dichroism, a powerful tool for the assessment of absolute configuration of flavonoids

Desmond Slade; Daneel Ferreira; Jannie P J Marais

doi:10.1016/j.phytochem.2005.02.002

Circular dichroism, a powerful tool for the assessment of absolute configuration of flavonoids

Phytochemistry. 2005 Sep;66(18):2177-215. doi: 10.1016/j.phytochem.2005.02.002.

Authors

Desmond Slade¹, Daneel Ferreira, Jannie P J Marais

Affiliation

¹ National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi University, MS 38677, USA. dslade@olemiss.edu

PMID: 16153414
DOI: 10.1016/j.phytochem.2005.02.002

Abstract

Circular dichroism is a powerful tool for establishing the absolute configuration of flavonoids and proanthocyanidin analogues. It has been utilized to study the configuration of flavanones, dihydroflavonols (3-hydroxyflavanones), flavan-3-ols, flavan-4-ols, flavan-3,4-diols, flavans, isoflavans, isoflavanones, pterocarpans, 6a-hydroxypterocarpans, rotenoids, 12a-hydroxyrotenoids, neoflavonoids, 3,4-dihydro-4-arylcoumarins, 4-arylflavan-3-ols, auronols, homoisoflavanones, proanthocyanidins, and various classes of biflavonoids. Results relevant to the correlation of circular dichroic data and the absolute configuration of the diastereoisomers of some of the above classes of compounds will be discussed.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Circular Dichroism*
Flavonoids / chemistry*
Molecular Structure

Substances

Flavonoids