Genetic analysis of the TOR pathway in Aspergillus nidulans

Eukaryot Cell. 2005 Sep;4(9):1595-8. doi: 10.1128/EC.4.9.1595-1598.2005.

Abstract

We identified five genes encoding components of the TOR signaling pathway within Aspergillus nidulans. Unlike the situation in Saccharomyces cerevisiae, there is only a single Tor kinase, as in plant and animal systems, and mutant phenotypes suggest that the TOR pathway plays only a minor role in regulating nitrogen metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antifungal Agents / pharmacology
  • Aspergillus nidulans / genetics*
  • Aspergillus nidulans / growth & development
  • Aspergillus nidulans / metabolism
  • Drug Resistance, Fungal
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism*
  • Gene Expression Regulation, Fungal
  • Molecular Sequence Data
  • Mutation / genetics*
  • Nitrogen / metabolism
  • Phenotype
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid
  • Signal Transduction*
  • Sirolimus / pharmacology
  • TOR Serine-Threonine Kinases

Substances

  • Antifungal Agents
  • Fungal Proteins
  • RNA, Messenger
  • Protein Kinases
  • TOR Serine-Threonine Kinases
  • Nitrogen
  • Sirolimus

Associated data

  • GENBANK/AJ717400
  • GENBANK/AJ717401
  • GENBANK/AJ717402
  • GENBANK/AJ717403
  • GENBANK/AJ717404