Abstract
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vbeta8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vbeta8(+) T cells, was significantly reduced and conferred protection from superantigen-induced mortality.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Enterotoxins / immunology*
-
Enterotoxins / pharmacology
-
HLA-DR2 Antigen / genetics
-
HLA-DR2 Antigen / immunology
-
Humans
-
Mice
-
Mice, Transgenic
-
Receptors, Antigen, T-Cell, alpha-beta / immunology*
-
Superantigens / immunology*
-
Superantigens / pharmacology
-
T-Lymphocytes / immunology*
-
Thymus Gland / cytology
-
Thymus Gland / immunology
Substances
-
Enterotoxins
-
HLA-DR2 Antigen
-
Receptors, Antigen, T-Cell, alpha-beta
-
Superantigens
-
enterotoxin B, staphylococcal