Abstract
Sensorineural hearing loss (SNHL) has been reported to develop as a main part of or in combination with systemic and organ-specific autoimmune diseases. The aim of the current study is to treat autoimmune SNHL in MRL/Mp-lpr/lpr (MRL/lpr) mice, a murine model of systemic autoimmune disease, using allogeneic bone marrow transplantation (BMT), which replaces recipient bone marrow cells with bone marrow cells from a non-autoimmune-prone donor. The results indicate that BMT can be used to treat SNHL; cochlear pathology, serum autoantibodies and lupus nephritis are ameliorated. Therefore, it is conceivable that the autoimmune SNHL in the MRL/lpr mice results not from defects in the cochlea, including the stria vascularis, but from defects in the bone marrow, and BMT would therefore provide a curative effect on inner ear autoimmune dysfunction associated with systemic autoimmune diseases.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acoustic Stimulation / methods
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Animals
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Autoantibodies / metabolism
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Autoimmune Diseases / surgery*
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Bone Marrow Transplantation / methods*
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Cochlea / metabolism
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Cochlea / pathology
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Cochlea / surgery
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DNA, Single-Stranded / immunology
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Disease Models, Animal
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Enzyme-Linked Immunosorbent Assay / methods
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Evoked Potentials, Auditory, Brain Stem / physiology
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Female
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Flow Cytometry / methods
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Hearing Loss, Sensorineural / genetics
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Hearing Loss, Sensorineural / surgery*
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Immunoglobulin G / immunology
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Immunohistochemistry / methods
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Lymphocytes / metabolism
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Mice
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Mice, Inbred C57BL
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Mice, Inbred MRL lpr / surgery
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Repressor Proteins / blood
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Rheumatoid Factor / metabolism
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Time Factors
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Transplantation, Homologous / methods
Substances
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Autoantibodies
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Cic protein, mouse
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DNA, Single-Stranded
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Immunoglobulin G
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Repressor Proteins
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Rheumatoid Factor