The thoughts of physicians regarding the need to start hormone replacement therapy in breast cancer survivors

Eur J Obstet Gynecol Reprod Biol. 2006 Feb 1;124(2):207-11. doi: 10.1016/j.ejogrb.2005.07.009. Epub 2005 Sep 6.

Abstract

Objectives: To investigate how physicians felt about HRT use in breast cancer survivors a half year after the WHI trial.

Methods: In December 2002, a questionnaire was conducted in Flanders (Belgium). The survey contained a presentation of a 35-year-old breast cancer survivor who presented with climacteric symptoms after treatment with tamoxifen.

Results: With a response rate of 33.65%, a majority of the physicians did not prescribe classical oral HRT (5.40%) in this patient. Physicians prefer to prescribe tibolone (30.68%) or other alternative treatment (50.00%). The main reason was the fear for increased recurrence of breast cancer. Furthermore the WHI oestrogen plus progestin trial and its attention in the media, a half year prior to the survey, influenced one-third of the physician's prescribing attitude.

Conclusions: Two-thirds of the physicians did not change prescribing attitude after the WHI oestrogen plus progestin trial. HRT is a well proven effective treatment in breast cancer survivors with severe climacteric complaints, but a majority of physicians is not convinced of its safety in breast cancer survivors. Therefore, a majority of physicians do not find the need to prescribe HRT in breast cancer survivors.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Attitude of Health Personnel*
  • Belgium
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / prevention & control*
  • Breast Neoplasms / psychology
  • Climacteric / drug effects
  • Female
  • Hormone Replacement Therapy / methods
  • Hormone Replacement Therapy / psychology*
  • Humans
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / prevention & control*
  • Neoplasm Recurrence, Local / psychology
  • Physicians / psychology*
  • Surveys and Questionnaires
  • Survivors*
  • Tamoxifen / therapeutic use

Substances

  • Antineoplastic Agents, Hormonal
  • Tamoxifen