Delayed effects of daphnia intoxication with selective and nonselective inhibitors of acetylcholinesterase

V V Zobov; L A Berezinskii; A A Aslyamova; V S Reznik

doi:10.1007/s10517-005-0214-5

Delayed effects of daphnia intoxication with selective and nonselective inhibitors of acetylcholinesterase

Bull Exp Biol Med. 2005 Jan;139(1):68-9. doi: 10.1007/s10517-005-0214-5.

Authors

V V Zobov¹, L A Berezinskii, A A Aslyamova, V S Reznik

Affiliation

¹ A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences, Russia.

PMID: 16142279
DOI: 10.1007/s10517-005-0214-5

Abstract

Chronic experiments on successive generations of laboratory Daphnia magna culture demonstrated higher (compared to proserin) embryotoxicity of a new selective acetylcholinesterase inhibitor 1,3-bis[5-(diethyl-o-nitrobenzilammonio)pentyl]-6-methyluracyl dibromide (compound No. 547). The concentrations of proserin (neostigmine) and compound No. 547 not exceeding 1/60 LC50 (0.39 mol/liter for compound No. 547 and 0.045 mol/liter for proserin) were absolutely safe for the reproductive function of daphnia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cholinesterase Inhibitors / toxicity*
Daphnia / drug effects
Daphnia / embryology
Embryo, Nonmammalian
Female
Fertility / drug effects
Neostigmine / toxicity*
Toxicity Tests
Uracil / analogs & derivatives*
Uracil / toxicity

Substances

Agent No. 547
Cholinesterase Inhibitors
Neostigmine
Uracil