Synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new bicyclic skeleton formed by ring expansion-RCM methodology

Nicolai Dieltiens; Diederica D Claeys; Bart Allaert; Francis Verpoort; Christian V Stevens

doi:10.1039/b508663a

Synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new bicyclic skeleton formed by ring expansion-RCM methodology

Chem Commun (Camb). 2005 Sep 21:(35):4477-8. doi: 10.1039/b508663a. Epub 2005 Aug 4.

Authors

Nicolai Dieltiens¹, Diederica D Claeys, Bart Allaert, Francis Verpoort, Christian V Stevens

Affiliation

¹ Research group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000, Ghent, Belgium.

PMID: 16136256
DOI: 10.1039/b508663a

Abstract

A short and elegant synthetic pathway was developed for the synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new 1,3-diazepan-2,4-dione containing bicyclic moiety, starting from pyroglutamate esters.