Abstract
Bioactivity-guided fractionation of an ethanol extract of the aerial parts of Dioscorea opposita afforded a new compound, 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (1), and four known compounds, chrysoeriol 4'-O-beta-D-glucopyranoside (2), chrysoeriol 7-O-beta-D-glucopyranoside (3), alternanthin (4), and daucosterol. The structure of 1 was established on the basis of the interpretation of its 1D and 2D NMR spectrascopic data. Compounds 1-4 exhibited both promising neuroprotective effects and discernible to moderate antioxidant activities in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology
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Dioscorea / chemistry*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification*
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Phenanthrenes / pharmacology
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Plants, Medicinal / chemistry*
Substances
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6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione
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Antioxidants
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Drugs, Chinese Herbal
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Neuroprotective Agents
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Phenanthrenes