Lignans from bark of Larix olgensis var. koreana

J Nat Prod. 2005 Aug;68(8):1175-9. doi: 10.1021/np058022s.

Abstract

Six new lignans (2-7) were isolated from the bark of Larix olgensis var. koreana, and their structures were determined on the basis of their spectroscopic data. Seven known lignans were also obtained and identified as (+)-lariciresinol 9'-p-coumarate (1), (+)-lariciresinol, (-)-secoisolariciresinol, (+)-isolariciresinol, vladinol D, sesquipinsapol B, and ehletianol C. Compound 1 showed weak inhibition against K562, SHG44, HCT-8, A549, and PC-3M tumor cells with IC50 values of 2.9, 21.4, 32.9, 33.8, and 28.0 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Butylene Glycols
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Inhibitory Concentration 50
  • Larix / chemistry*
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Stereoisomerism
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Butylene Glycols
  • Drugs, Chinese Herbal
  • Furans
  • Lignans
  • lariciresinol
  • secoisolariciresinol