Palladium-catalyzed cyanation of porphyrins utilizing cyanoethylzinc bromide as an efficient cyanide ion source

Toshikatsu Takanami; Mikiko Hayashi; Hiroshi Chijimatsu; Wakaba Inoue; Kohji Suda

doi:10.1021/ol0514294

Palladium-catalyzed cyanation of porphyrins utilizing cyanoethylzinc bromide as an efficient cyanide ion source

Org Lett. 2005 Sep 1;7(18):3937-40. doi: 10.1021/ol0514294.

Authors

Toshikatsu Takanami¹, Mikiko Hayashi, Hiroshi Chijimatsu, Wakaba Inoue, Kohji Suda

Affiliation

¹ Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

PMID: 16119936
DOI: 10.1021/ol0514294

Abstract

Palladium-catalyzed cyanation of bromoporphyrins is now realized using cyanoethylzinc bromide as a specific cyanating agent. This new protocol provides an easy access to various cyanated Zn(II) porphyrins, including meso-mono-, meso-di-, and beta-mono-cyano-substituted Zn(II) complexes. [reaction: see text]