Aptamer biosensor for label-free impedance spectroscopy detection of proteins based on recognition-induced switching of the surface charge

Chem Commun (Camb). 2005 Sep 14:(34):4267-9. doi: 10.1039/b506571b. Epub 2005 Jul 12.

Abstract

The recognition of proteins by aptamer-modified electrode transducers reverses the surface charge and leads to a novel label-free impedance spectroscopy bioelectronic detection protocol based on a decrease in the electron transfer resistance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biosensing Techniques*
  • Biotin / chemistry
  • Electric Impedance
  • Electrochemistry
  • Electrodes
  • Muramidase / chemistry
  • Proteins / chemistry*
  • Solutions
  • Spectrophotometry
  • Surface Properties

Substances

  • Proteins
  • Solutions
  • Biotin
  • Muramidase