An antitumor compound julibroside J28 from Albizia julibrissin

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4493-5. doi: 10.1016/j.bmcl.2005.07.015.

Abstract

A new triterpenoid saponin, julibroside J(28) (1), was isolated from the stem bark of Albizia julibrissin Durazz (Leguminosae) by using chromatographic method. The structure of 1 was established by spectroscopic methods. 1 displayed significant antitumor activity in vitro against PC-3M-1E8, Bel-7402, and HeLa cancer cell lines at 10 microM assayed by SRB method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Carbohydrate Sequence
  • Cell Line, Tumor
  • Fabaceae / chemistry*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Saponins
  • Triterpenes
  • julibroside J28